6Q8I

Nterminal domain of human SMU1 in complex with human REDmid

Summary for 6Q8I

Related6Q8F
DescriptorWD40 repeat-containing protein SMU1, Protein Red (3 entities in total)
Functional Keywordssplicing factor, minimal red-smu1 complex, splicing
Biological sourceHomo sapiens (Human)
Total number of polymer chains16
Total molecular weight986937.96
Authors
Primary citation
Ashraf, U.,Tengo, L.,Le Corre, L.,Fournier, G.,Busca, P.,McCarthy, A.A.,Rameix-Welti, M.A.,Gravier-Pelletier, C.,Ruigrok, R.W.H.,Jacob, Y.,Vidalain, P.O.,Pietrancosta, N.,Crepin, T.,Naffakh, N.
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
Proc.Natl.Acad.Sci.USA, 116:10968-10977, 2019
PubMed: 31076555 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1901214116
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.17 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.3263 0.9% 6.4% 11.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution