6Q8A

Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine

Summary for 6Q8A

Related6I5Y 6HB7 6HB5 6HB6
DescriptorLeucine--tRNA ligase, 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine, ZINC ION, ... (5 entities in total)
Functional Keywordsprotein-inhibitor complex, rossmann fold, trna synthetase, ligase
Biological sourceNeisseria gonorrhoeae (strain NCCP11945)
Total number of polymer chains1
Total molecular weight98710.51
Authors
Pang, L.,De Graef, S.,Strelkov, S.V.,Weeks, S.D. (deposition date: 2018-12-14, release date: 2019-04-17, Last modification date: 2019-05-01)
Primary citation
Nautiyal, M.,De Graef, S.,Pang, L.,Gadakh, B.,Strelkov, S.V.,Weeks, S.D.,Van Aerschot, A.
Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
Eur.J.Med.Chem., 173:154-166, 2019
PubMed: 30995568 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2019.04.003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.11 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2484 0.5% 2.3% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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