6Q5B

OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance

Summary for 6Q5B

DescriptorBeta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ... (7 entities in total)
Functional Keywordsoxa-48, ceftazidime, avibactam, resistance development, evolution, escherichia coli, klebsiella pneumoniae, carbapenemase, carbapenem, antibiotic
Biological sourceKlebsiella pneumoniae
Total number of polymer chains4
Total molecular weight122963.68
Authors
Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.K.S.,Samuelsen, O. (deposition date: 2018-12-07, release date: 2019-03-20)
Primary citation
Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.K.S.,Samuelsen, O.
Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance
To be published,
Experimental method
X-RAY DIFFRACTION (2.22 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2623 0.3% 2.3% 3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6q5b
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Molmil generated image of 6q5b
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Molmil generated image of 6q5b
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6q5b
no rotation
Molmil generated image of 6q5b
rotated about x axis by 90°
Molmil generated image of 6q5b
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6q5b.pdb1.gz [160.38 KB])
Coordinate files for Biological unit (6q5b.pdb2.gz [160.02 KB])