6Q5B

OXA-48_P68A-AVI. Evolutionary trade-offs of OXA-48 mediated ceftazidime-avibactam resistance

Summary for 6Q5B

• Entry DOI: 10.2210/pdb6q5b/pdb
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, CARBON DIOXIDE, ... (7 entities in total)
• Functional Keywords: oxa-48, ceftazidime, avibactam, resistance development, evolution, escherichia coli, klebsiella pneumoniae, carbapenemase, carbapenem, antibiotic
• Biological source: Klebsiella pneumoniae; More
• Total number of polymer chains: 4
• Total formula weight: 122963.68

Authors

Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.K.S.,Samuelsen, O. (deposition date: 2018-12-07, release date: 2019-03-20, Last modification date: 2024-01-24)

• Primary citation: Frohlich, C.,Sorum, V.,Thomassen, A.M.,Johnsen, P.J.,Leiros, H.S.,Samuelsen, O.; OXA-48-Mediated Ceftazidime-Avibactam Resistance Is Associated with Evolutionary Trade-Offs.; Msphere, 4:-, 2019; PubMed: 30918055; DOI: 10.1128/mSphere.00024-19

Experimental method

X-RAY DIFFRACTION (2.22 Å)