Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution

Summary for 6Q54

DescriptorGlutamate receptor 2, SULFATE ION, (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, ... (10 entities in total)
Functional Keywordsionotropic glutamate receptor, ampa receptor, ligand-binding domain, glua2-s1s2, glua2, glur2, agonist, membrane protein
Biological sourceRattus norvegicus (Rat)
Total number of polymer chains2
Total molecular weight61012.63
Moellerud, S.,Temperini, P.,Kastrup, J.S. (deposition date: 2018-12-07, release date: 2019-04-17, Last modification date: 2019-05-22)
Primary citation
Sainas, S.,Temperini, P.,Farnsworth, J.C.,Yi, F.,Mollerud, S.,Jensen, A.A.,Nielsen, B.,Passoni, A.,Kastrup, J.S.,Hansen, K.B.,Boschi, D.,Pickering, D.S.,Clausen, R.P.,Lolli, M.L.
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.
J.Med.Chem., 62:4467-4482, 2019
PubMed: 30943028 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.8b01986
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.16400 0.9% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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