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6Q49

CDK2 in complex with FragLite6

Summary for 6Q49
Entry DOI10.2210/pdb6q49/pdb
DescriptorCyclin-dependent kinase 2, DIMETHYL SULFOXIDE, 4-bromanyl-1~{H}-pyridin-2-one, ... (4 entities in total)
Functional Keywordsfragment, fraglite, cdk2, inhibitor, cell cycle
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight35013.48
Authors
Wood, D.J.,Martin, M.P.,Noble, M.E.M. (deposition date: 2018-12-05, release date: 2019-03-20, Last modification date: 2024-01-24)
Primary citationWood, D.J.,Lopez-Fernandez, J.D.,Knight, L.E.,Al-Khawaldeh, I.,Gai, C.,Lin, S.,Martin, M.P.,Miller, D.C.,Cano, C.,Endicott, J.A.,Hardcastle, I.R.,Noble, M.E.M.,Waring, M.J.
FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation.
J.Med.Chem., 62:3741-3752, 2019
Cited by
PubMed: 30860382
DOI: 10.1021/acs.jmedchem.9b00304
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1 Å)
Structure validation

217705

数据于2024-03-27公开中

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