Crystal Structure of ABBV-323 FAB

Summary for 6PE7

DescriptorFAB Heavy Chain, FAB Light chain, SULFATE ION, ... (4 entities in total)
Functional Keywordscd40, fab, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight48231.68
Argiriadi, M.A. (deposition date: 2019-06-20, release date: 2019-08-14)
Primary citation
Argiriadi, M.A.,Benatuil, L.,Dubrovska, I.,Egan, D.A.,Gao, L.,Greischar, A.,Hardman, J.,Harlan, J.,Iyer, R.B.,Judge, R.A.,Lake, M.,Perron, D.C.,Sadhukhan, R.,Sielaff, B.,Sousa, S.,Wang, R.,McRae, B.L.
CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches.
BMC Mol Cell Biol, 20:29-29, 2019
PubMed: 31382872 (PDB entries with the same primary citation)
DOI: 10.1186/s12860-019-0213-4
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23520 0.8% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution