6PA7
The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.
Summary for 6PA7
Entry DOI | 10.2210/pdb6pa7/pdb |
EMDB information | 20281 21689 |
Descriptor | Histone H3.2, S-ADENOSYL-L-HOMOCYSTEINE, Histone H4, ... (10 entities in total) |
Functional Keywords | methyltransferase, complex, transferase, transferase-dna complex, transferase/dna |
Biological source | Xenopus laevis (African clawed frog) More |
Total number of polymer chains | 14 |
Total formula weight | 541073.19 |
Authors | Xu, T.H.,Liu, M.,Zhou, X.E.,Liang, G.,Zhao, G.,Xu, H.E.,Melcher, K.,Jones, P.A. (deposition date: 2019-06-11, release date: 2020-06-17, Last modification date: 2024-03-20) |
Primary citation | Xu, T.H.,Liu, M.,Zhou, X.E.,Liang, G.,Zhao, G.,Xu, H.E.,Melcher, K.,Jones, P.A. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature, 586:151-155, 2020 Cited by PubMed: 32968275DOI: 10.1038/s41586-020-2747-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.94 Å) |
Structure validation
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