6P7I

Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound

Summary for 6P7I

DescriptorProtein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, ... (6 entities in total)
Functional Keywordsprotein arginine methyltransferase, prmt6, hrmt1l6, prmt inhibitors, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight171215.62
Authors
Primary citation
Halabelian, L.,Dong, A.,Zeng, H.,Li, Y.,Seitova, A.,Hutchinson, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC)
Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Comp ound
to be published,
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22710 1.9% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report