6P7I

Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound

Summary for 6P7I

• Entry DOI: 10.2210/pdb6p7i/pdb
• Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide, ... (6 entities in total)
• Functional Keywords: protein arginine methyltransferase, prmt6, hrmt1l6, prmt inhibitors, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 171215.62

Authors

Halabelian, L.,Dong, A.,Zeng, H.,Li, Y.,Seitova, A.,Hutchinson, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2019-06-05, release date: 2019-06-26, Last modification date: 2023-10-11)

• Primary citation: Shen, Y.,Li, F.,Szewczyk, M.M.,Halabelian, L.,Park, K.S.,Chau, I.,Dong, A.,Zeng, H.,Chen, H.,Meng, F.,Barsyte-Lovejoy, D.,Arrowsmith, C.H.,Brown, P.J.,Liu, J.,Vedadi, M.,Jin, J.; Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor; J.Med.Chem., 63:5477-5487, 2020; DOI: 10.1021/acs.jmedchem.0c00406

Experimental method

X-RAY DIFFRACTION (2 Å)