Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR

Summary for 6ORQ

EMDB information20178
DescriptorRC1 variant of HIV-1 Env glycoprotein gp41, RC1 variant of HIV-1 Env glycoprotein gp120, Ab275MUR antibody Fab heavy chain, ... (7 entities in total)
Functional Keywordshiv-1 broadly-neutralizing antibody, env trimer structure, v3-glycan patch, cryo-em, rc1, immunogen design, viral protein-immune system complex, antiviral protein, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains12
Total molecular weight355363.49
Abernathy, M.E.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2019-04-30, release date: 2019-06-12)
Primary citation
Escolano, A.,Gristick, H.B.,Abernathy, M.E.,Merkenschlager, J.,Gautam, R.,Oliveira, T.Y.,Pai, J.,West Jr., A.P.,Barnes, C.O.,Cohen, A.A.,Wang, H.,Golijanin, J.,Yost, D.,Keeffe, J.R.,Wang, Z.,Zhao, P.,Yao, K.H.,Bauer, J.,Nogueira, L.,Gao, H.,Voll, A.V.,Montefiori, D.C.,Seaman, M.S.,Gazumyan, A.,Silva, M.,McGuire, A.T.,Stamatatos, L.,Irvine, D.J.,Wells, L.,Martin, M.A.,Bjorkman, P.J.,Nussenzweig, M.C.
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature, 2019
PubMed: 31142836 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-1250-z
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers6 0.3% 1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures