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6ORO

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP

Summary for 6ORO
Entry DOI10.2210/pdb6oro/pdb
EMDB information20176
DescriptorRC1 variant of HIV-1 Env glycoprotein gp41, RC1 variant of HIV-1 Env glycoprotein gp120, Ab874NHP antibody Fab heavy chain, ... (9 entities in total)
Functional Keywordshiv-1 broadly-neutralizing antibody, env trimer structure, v3-glycan patch, cryo-em, rc1, immunogen design, antiviral protein-immune system complex, antiviral protein, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman immunodeficiency virus 1
More
Total number of polymer chains12
Total formula weight388288.09
Authors
Abernathy, M.E.,Gristick, H.B.,Bjorkman, P.J. (deposition date: 2019-04-30, release date: 2019-06-12, Last modification date: 2020-07-29)
Primary citationEscolano, A.,Gristick, H.B.,Abernathy, M.E.,Merkenschlager, J.,Gautam, R.,Oliveira, T.Y.,Pai, J.,West Jr., A.P.,Barnes, C.O.,Cohen, A.A.,Wang, H.,Golijanin, J.,Yost, D.,Keeffe, J.R.,Wang, Z.,Zhao, P.,Yao, K.H.,Bauer, J.,Nogueira, L.,Gao, H.,Voll, A.V.,Montefiori, D.C.,Seaman, M.S.,Gazumyan, A.,Silva, M.,McGuire, A.T.,Stamatatos, L.,Irvine, D.J.,Wells, L.,Martin, M.A.,Bjorkman, P.J.,Nussenzweig, M.C.
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature, 570:468-473, 2019
Cited by
PubMed: 31142836
DOI: 10.1038/s41586-019-1250-z
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.9 Å)
Structure validation

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