Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)

This is a large structure.

Summary for 6OLG

EMDB information0601 0600 0599 0526 0596 0598 0597
Descriptor60S ribosomal protein L8, 40S ribosomal protein SA, 60S ribosomal protein L3, ... (88 entities in total)
Functional Keywordsselective stalling, drug-like molecule, human ribosome nascent chain complex, ribosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains85
Total molecular weight3206720.29
Li, W.,Cate, J.H.D. (deposition date: 2019-04-16, release date: 2019-06-19)
Primary citation
Li, W.,Ward, F.R.,McClure, K.F.,Chang, S.T.,Montabana, E.,Liras, S.,Dullea, R.G.,Cate, J.H.D.
Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26:501-509, 2019
PubMed: 31160784 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-019-0236-8
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone8 0.9% 2.1% 0.48MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures