6OKO

Crystal structure of mRIPK3 complexed with N-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Summary for 6OKO

• Entry DOI: 10.2210/pdb6oko/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 3, 1-(4-fluorophenyl)-N-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase, ripk3, rip3, transferase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 2
• Total formula weight: 73343.49

Authors

Pokross, M.E. (deposition date: 2019-04-14, release date: 2019-07-17, Last modification date: 2024-03-13)

• Primary citation: Hart, A.C.,Abell, L.,Guo, J.,Mertzman, M.E.,Padmanabha, R.,Macor, J.E.,Chaudhry, C.,Lu, H.,O'Malley, K.,Shaw, P.J.,Weigelt, C.,Pokross, M.,Kish, K.,Kim, K.S.,Cornelius, L.,Douglas, A.E.,Calambur, D.,Zhang, P.,Carpenter, B.,Pitts, W.J.; Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.; Acs Med.Chem.Lett., 11:266-271, 2020; PubMed: 32184955; DOI: 10.1021/acsmedchemlett.9b00065

Experimental method

X-RAY DIFFRACTION (2.1 Å)