6OJB

Crystal Structure of Aspergillus fumigatus Ega3 complex with galactosamine

Summary for 6OJB

• Entry DOI: 10.2210/pdb6ojb/pdb
• Descriptor: Endo alpha-1,4 polygalactosaminidase, alpha-D-mannopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: galactosaminidase, (beta/alpha)-barrel, glycoside hydrolase, hydrolase
• Biological source: Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
• Total number of polymer chains: 1
• Total formula weight: 35902.72

Authors

Bamford, N.C.,Howell, P.L. (deposition date: 2019-04-11, release date: 2019-08-14, Last modification date: 2023-10-11)

• Primary citation: Bamford, N.C.,Le Mauff, F.,Subramanian, A.S.,Yip, P.,Millan, C.,Zhang, Y.,Zacharias, C.,Forman, A.,Nitz, M.,Codee, J.D.C.,Uson, I.,Sheppard, D.C.,Howell, P.L.; Ega3 from the fungal pathogenAspergillus fumigatusis an endo-alpha-1,4-galactosaminidase that disrupts microbial biofilms.; J.Biol.Chem., 294:13833-13849, 2019; PubMed: 31416836; DOI: 10.1074/jbc.RA119.009910

Experimental method

X-RAY DIFFRACTION (2.093 Å)