Crystal structure of (E)-biformene synthase LrdC from Streptomyces sp. strain K155 in the dimeric form

Replaces:  5A0I

Summary for 6OH8

DescriptorLabdane-related diterpene synthase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... (4 entities in total)
Functional Keywordsbioactive natural products, biformene, diterpene synthase, labdatriene, lyase
Biological sourceStreptomyces sp.
Total number of polymer chains2
Total molecular weight75102.91
Centeno-Leija, S.,Serrano-Posada, H. (deposition date: 2019-04-04, release date: 2019-04-17, Last modification date: 2019-04-24)
Primary citation
Centeno-Leija, S.,Tapia-Cabrera, S.,Guzman-Trampe, S.,Esquivel, B.,Esturau-Escofet, N.,Tierrafria, V.H.,Rodriguez-Sanoja, R.,Zarate-Romero, A.,Stojanoff, V.,Rudino-Pinera, E.,Sanchez, S.,Serrano-Posada, H.
The structure of (E)-biformene synthase provides insights into the biosynthesis of bacterial bicyclic labdane-related diterpenoids.
J. Struct. Biol., 2019
PubMed: 30981884 (PDB entries with the same primary citation)
DOI: 10.1016/j.jsb.2019.04.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2389 1.3% 3.2% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6oh8
no rotation
Molmil generated image of 6oh8
rotated about x axis by 90°
Molmil generated image of 6oh8
rotated about y axis by 90°