6OA1

Structure of human PARG complexed with JA2120

Summary for 6OA1

Entry DOI	10.2210/pdb6oa1/pdb
Related	6O9X 6O9Y 6OA0
Descriptor	Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione (3 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	61549.02
Authors	Stegeman, R.A.,Jones, D.E.,Ellenberger, T.,Kim, I.K.,Tainer, J.A. (deposition date: 2019-03-15, release date: 2019-12-25, Last modification date: 2024-03-13)
Primary citation	Houl, J.H.,Ye, Z.,Brosey, C.A.,Balapiti-Modarage, L.P.F.,Namjoshi, S.,Bacolla, A.,Laverty, D.,Walker, B.L.,Pourfarjam, Y.,Warden, L.S.,Babu Chinnam, N.,Moiani, D.,Stegeman, R.A.,Chen, M.K.,Hung, M.C.,Nagel, Z.D.,Ellenberger, T.,Kim, I.K.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun, 10:5654-5654, 2019 Cited by PubMed: 31827085 DOI: 10.1038/s41467-019-13508-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation