6O9X

Structure of human PARG complexed with JA2-4

6O9X の概要

• エントリーDOI: 10.2210/pdb6o9x/pdb
• 分子名称: Poly(ADP-ribose) glycohydrolase, 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one (3 entities in total)
• 機能のキーワード: hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61549.09

構造登録者

Stegeman, R.A.,Jones, D.E.,Ellenberger, T.,Kim, I.K.,Tainer, J.A. (登録日: 2019-03-15, 公開日: 2019-12-25, 最終更新日: 2024-03-13)

• 主引用文献: Houl, J.H.,Ye, Z.,Brosey, C.A.,Balapiti-Modarage, L.P.F.,Namjoshi, S.,Bacolla, A.,Laverty, D.,Walker, B.L.,Pourfarjam, Y.,Warden, L.S.,Babu Chinnam, N.,Moiani, D.,Stegeman, R.A.,Chen, M.K.,Hung, M.C.,Nagel, Z.D.,Ellenberger, T.,Kim, I.K.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.; Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.; Nat Commun, 10:5654-5654, 2019; PubMed: 31827085; DOI: 10.1038/s41467-019-13508-4

実験手法

X-RAY DIFFRACTION (1.7 Å)