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6O95

Structure of the IRAK4 kinase domain with compound 41

Summary for 6O95
Entry DOI10.2210/pdb6o95/pdb
DescriptorInterleukin-1 receptor-associated kinase 4, SULFATE ION, N-[(2R)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
Functional Keywordskinase, irak4, irak1, irak2, irak3, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight146608.07
Authors
Yu, C.,Drobnick, J.,Bryan, M.C.,Kiefer, J.,Lupardus, P.J. (deposition date: 2019-03-13, release date: 2019-05-22, Last modification date: 2019-07-24)
Primary citationBryan, M.C.,Drobnick, J.,Gobbi, A.,Kolesnikov, A.,Chen, Y.,Rajapaksa, N.,Ndubaku, C.,Feng, J.,Chang, W.,Francis, R.,Yu, C.,Choo, E.F.,DeMent, K.,Ran, Y.,An, L.,Emson, C.,Huang, Z.,Sujatha-Bhaskar, S.,Brightbill, H.,DiPasquale, A.,Maher, J.,Wai, J.,McKenzie, B.S.,Lupardus, P.J.,Zarrin, A.A.,Kiefer, J.R.
Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors.
J.Med.Chem., 62:6223-6240, 2019
Cited by
PubMed: 31082230
DOI: 10.1021/acs.jmedchem.9b00439
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

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