6O57

Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 with a substrate analog p2-NC in P41

Summary for 6O57

Entry DOI	10.2210/pdb6o57/pdb
Related	2AOD 5T2E 6O48 6O54 6O5X
Related PRD ID	PRD_000398
Descriptor	HIV-1 protease, FORMIC ACID, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, ... (4 entities in total)
Functional Keywords	hiv protease, hydrolase, viral protein
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22538.27
Authors	Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-03-01, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. Acs Omega, 4:8707-8719, 2019 Cited by PubMed: 31172041 DOI: 10.1021/acsomega.9b00683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation