6O54

Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 (D25N)

Summary for 6O54

Related5T2E
DescriptorHIV-1 protease, CHLORIDE ION (3 entities in total)
Functional Keywordshiv protease, hydrolase, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains1
Total molecular weight10932.42
Authors
Wang, Y.-F.,Brothers, R.,Agniswamy, J.,Weber, I.T. (deposition date: 2019-03-01, release date: 2019-06-19, Last modification date: 2019-07-17)
Primary citation
Agniswamy, J.,Kneller, D.W.,Brothers, R.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.
Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.
Acs Omega, 4:8707-8719, 2019
PubMed: 31172041 (PDB entries with the same primary citation)
DOI: 10.1021/acsomega.9b00683
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.21 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.166300 5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution