6O21

Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor

Summary for 6O21

• Entry DOI: 10.2210/pdb6o21/pdb
• Related PRD ID: PRD_001059
• Descriptor: Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a, Trypsin inhibitor 1, SULFATE ION, ... (5 entities in total)
• Functional Keywords: kallikrein-related peptidase 4, klk4, sunflower trypsin inhibitor, sfti, laskowski mechanism inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 25912.24

Authors

Ilyichova, O.V.,Buckle, A.M. (deposition date: 2019-02-22, release date: 2019-03-13, Last modification date: 2023-10-11)

• Primary citation: Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M.; KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors.; Biochemistry, 58:2524-2533, 2019; PubMed: 31058493; DOI: 10.1021/acs.biochem.9b00191

Experimental method

X-RAY DIFFRACTION (1.15 Å)