6O21
Crystal Structure of Human KLK4 in Complex With Cleaved SFTI-FCQR(Asn14)[1,14] Inhibitor
6O21 の概要
エントリーDOI | 10.2210/pdb6o21/pdb |
関連するBIRD辞書のPRD_ID | PRD_001059 |
分子名称 | Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a, Trypsin inhibitor 1, SULFATE ION, ... (5 entities in total) |
機能のキーワード | kallikrein-related peptidase 4, klk4, sunflower trypsin inhibitor, sfti, laskowski mechanism inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 25912.24 |
構造登録者 | |
主引用文献 | Riley, B.T.,Ilyichova, O.,de Veer, S.J.,Swedberg, J.E.,Wilson, E.,Hoke, D.E.,Harris, J.M.,Buckle, A.M. KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors. Biochemistry, 58:2524-2533, 2019 Cited by PubMed: 31058493DOI: 10.1021/acs.biochem.9b00191 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.15 Å) |
構造検証レポート
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