6O0O

crystal structure of BCL-2 G101V mutation with S55746

6O0O の概要

• エントリーDOI: 10.2210/pdb6o0o/pdb
• 分子名称: Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2, ~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide (3 entities in total)
• 機能のキーワード: bcl-2, s55746, complex, protein-protein interface inhibitor, resistance mutation, apoptosis
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40220.91

構造登録者

Birkinshaw, R.W.,Luo, C.S.,Colman, P.M.,Czabotar, P.E. (登録日: 2019-02-17, 公開日: 2019-05-22, 最終更新日: 2023-10-11)

• 主引用文献: Birkinshaw, R.W.,Gong, J.N.,Luo, C.S.,Lio, D.,White, C.A.,Anderson, M.A.,Blombery, P.,Lessene, G.,Majewski, I.J.,Thijssen, R.,Roberts, A.W.,Huang, D.C.S.,Colman, P.M.,Czabotar, P.E.; Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations.; Nat Commun, 10:2385-2385, 2019; PubMed: 31160589; DOI: 10.1038/s41467-019-10363-1

実験手法

X-RAY DIFFRACTION (1.998 Å)