6NQ2

Cryo-EM structure of human TPC2 channel in the ligand-bound closed state

Summary for 6NQ2

• Entry DOI: 10.2210/pdb6nq2/pdb
• EMDB information: 0477 0478 0479
• Descriptor: Two pore calcium channel protein 2, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (2 entities in total)
• Functional Keywords: channel, lysosome, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 172836.79

Authors

She, J.,Zeng, W.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y. (deposition date: 2019-01-18, release date: 2019-03-27, Last modification date: 2019-11-20)

• Primary citation: She, J.,Zeng, W.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y.; Structural mechanisms of phospholipid activation of the human TPC2 channel.; Elife, 8:-, 2019; PubMed: 30860481; DOI: 10.7554/eLife.45222

Experimental method

ELECTRON MICROSCOPY (3.4 Å)