6NPT

TRK-A IN COMPLEX WITH LIGAND 1

Summary for 6NPT

Entry DOI	10.2210/pdb6npt/pdb
Descriptor	High affinity nerve growth factor receptor, 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (3 entities in total)
Functional Keywords	trk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	35217.52
Authors	Subramanian, G. (deposition date: 2019-01-18, release date: 2019-05-22, Last modification date: 2019-07-10)
Primary citation	Subramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.A.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L. Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A ( hTrkA) Inhibitors. Acs Chem.Biol., 14:1205-1216, 2019 Cited by PubMed: 31059222 DOI: 10.1021/acschembio.9b00126 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.19 Å)

Structure validation