6NPT

TRK-A IN COMPLEX WITH LIGAND 1

Summary for 6NPT

DescriptorHigh affinity nerve growth factor receptor, 4-tert-butyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (3 entities in total)
Functional Keywordstrk-a kinase domain high affinity nerve growth factor receptor inhibitor, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight35217.52
Authors
Subramanian, G. (deposition date: 2019-01-18, release date: 2019-05-22)
Primary citation
Subramanian, G.,Johnson, P.D.,Zachary, T.,Roush, N.,Zhu, Y.,Bowen, S.J.,Janssen, A.,Duclos, B.,Williams, T.,Javens, C.,Shalaly, N.D.,Molina, D.M.,Wittwer, A.J.,Hirsch, J.L.
Deciphering the allosteric binding mechanism of the human tropomyosin receptor kinase A (hTrkA) inhibitors.
Acs Chem.Biol., 2019
PubMed: 31059222 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.9b00126
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.19 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2811 0.4% 0.4% 3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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