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6NNV

PD-L1 IgV domain complex with macro-cyclic peptide

Summary for 6NNV
Entry DOI10.2210/pdb6nnv/pdb
DescriptorProgrammed cell death 1 ligand 1, macrocyclic peptide (3 entities in total)
Functional Keywordsfragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight65583.27
Authors
Zhao, B.,Perry, E. (deposition date: 2019-01-15, release date: 2019-02-20, Last modification date: 2023-10-11)
Primary citationPerry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.
Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29:786-790, 2019
Cited by
PubMed: 30728114
DOI: 10.1016/j.bmcl.2019.01.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.92 Å)
Structure validation

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