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6NNI

Structure of closed state of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pyrimethamine

Summary for 6NNI
Entry DOI10.2210/pdb6nni/pdb
DescriptorDihydrofolate reductase, COBALT (II) ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
Functional Keywordsantifolate, biosynthetic protein
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains2
Total formula weight38202.84
Authors
Ribeiro, J.A.,Chavez-Pacheco, S.M.,Dias, M.V.B. (deposition date: 2019-01-15, release date: 2019-07-17, Last modification date: 2024-03-13)
Primary citationRibeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B.
Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates.
Acta Crystallogr D Struct Biol, 75:682-693, 2019
Cited by
PubMed: 31282477
DOI: 10.1107/S205979831900901X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.561 Å)
Structure validation

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