6NNG

Tubulin-RB3_SLD-TTL in complex with compound DJ95

Summary for 6NNG

• Entry DOI: 10.2210/pdb6nng/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• Functional Keywords: microtubule inhibitor, colchicine, cancer, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 264791.21

Authors

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2019-01-15, release date: 2019-07-10, Last modification date: 2019-12-04)

• Primary citation: Arnst, K.E.,Wang, Y.,Lei, Z.N.,Hwang, D.J.,Kumar, G.,Ma, D.,Parke, D.N.,Chen, Q.,Yang, J.,White, S.W.,Seagroves, T.N.,Chen, Z.S.,Miller, D.D.,Li, W.; Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.; Mol.Pharmacol., 96:73-89, 2019; PubMed: 31043459; DOI: 10.1124/mol.118.114801

Experimental method

X-RAY DIFFRACTION (2.397 Å)