6NNC

Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pemetrexed

Summary for 6NNC

Entry DOI	10.2210/pdb6nnc/pdb
Descriptor	Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, COBALT (II) ION, ... (6 entities in total)
Functional Keywords	antifolate, biosynthetic protein
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	2
Total formula weight	38169.77
Authors	Ribeiro, J.A.,Chavez-Pacheco, S.M.,Dias, M.V.B. (deposition date: 2019-01-14, release date: 2019-07-17, Last modification date: 2024-03-13)
Primary citation	Ribeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. Acta Crystallogr D Struct Biol, 75:682-693, 2019 Cited by PubMed: 31282477 DOI: 10.1107/S205979831900901X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation