6NNC
Structure of Dihydrofolate reductase from Mycobacterium tuberculosis in complex with NADPH and pemetrexed
Summary for 6NNC
Entry DOI | 10.2210/pdb6nnc/pdb |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, COBALT (II) ION, ... (6 entities in total) |
Functional Keywords | antifolate, biosynthetic protein |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 2 |
Total formula weight | 38169.77 |
Authors | Ribeiro, J.A.,Chavez-Pacheco, S.M.,Dias, M.V.B. (deposition date: 2019-01-14, release date: 2019-07-17, Last modification date: 2024-03-13) |
Primary citation | Ribeiro, J.A.,Chavez-Pacheco, S.M.,de Oliveira, G.S.,Silva, C.D.S.,Giudice, J.H.P.,Libreros-Zuniga, G.A.,Dias, M.V.B. Crystal structures of the closed form of Mycobacterium tuberculosis dihydrofolate reductase in complex with dihydrofolate and antifolates. Acta Crystallogr D Struct Biol, 75:682-693, 2019 Cited by PubMed: 31282477DOI: 10.1107/S205979831900901X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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