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6NN8

The structure of human liver pyruvate kinase, hLPYK-S531E

Summary for 6NN8
Entry DOI10.2210/pdb6nn8/pdb
DescriptorPyruvate kinase PKLR, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywordspyruvate kinase, allosteric, glycolysis, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total formula weight471394.38
Authors
McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Fenton, A.W.,Lamb, A.L. (deposition date: 2019-01-14, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citationMcFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Chilton, A.,Fenton, A.W.,Lamb, A.L.
Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond.
Acta Crystallogr.,Sect.F, 75:461-469, 2019
Cited by
PubMed: 31204694
DOI: 10.1107/S2053230X19007209
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.416 Å)
Structure validation

217705

数据于2024-03-27公开中

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