6NN8

The structure of human liver pyruvate kinase, hLPYK-S531E

Summary for 6NN8

DescriptorPyruvate kinase PKLR, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywordspyruvate kinase, allosteric, glycolysis, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains8
Total molecular weight471394.38
Authors
McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Fenton, A.W.,Lamb, A.L. (deposition date: 2019-01-14, release date: 2019-06-19)
Primary citation
McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Chilton, A.,Fenton, A.W.,Lamb, A.L.
Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond
Acta Crystallogr.,Sect.F, 75:461-469, 2019
DOI: 10.1107/s2053230x19007209
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.416 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26010 0.9% 3.1% 7.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution