6NN4

The structure of human liver pyruvate kinase, hLPYK-D499N, in complex with Fru-1,6-BP

Summary for 6NN4

Entry DOI	10.2210/pdb6nn4/pdb
Descriptor	Pyruvate kinase PKLR, 1,6-di-O-phosphono-beta-D-fructofuranose, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	pyruvate kinase, allosteric, glycolysis, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	236719.81
Authors	McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Fenton, A.W.,Lamb, A.L. (deposition date: 2019-01-14, release date: 2019-06-19, Last modification date: 2023-10-11)
Primary citation	McFarlane, J.S.,Ronnebaum, T.A.,Meneely, K.M.,Chilton, A.,Fenton, A.W.,Lamb, A.L. Changes in the allosteric site of human liver pyruvate kinase upon activator binding include the breakage of an intersubunit cation-pi bond. Acta Crystallogr.,Sect.F, 75:461-469, 2019 Cited by PubMed: 31204694 DOI: 10.1107/S2053230X19007209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation