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6NM7

PD-L1 IgV domain bound to fragment

Summary for 6NM7
Entry DOI10.2210/pdb6nm7/pdb
DescriptorProgrammed cell death 1 ligand 1, 5-phenylthieno[2,3-d]pyrimidin-4(3H)-one (3 entities in total)
Functional Keywordsfragment-based screening, structure-based design, pd-l1 inhibitor, cancer drug discovery, immunotherapy, immune system, immune system-inhibitor complex, immune system/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight29852.13
Authors
Perry, E.,Zhao, B. (deposition date: 2019-01-10, release date: 2019-02-20, Last modification date: 2023-10-11)
Primary citationPerry, E.,Mills, J.J.,Zhao, B.,Wang, F.,Sun, Q.,Christov, P.P.,Tarr, J.C.,Rietz, T.A.,Olejniczak, E.T.,Lee, T.,Fesik, S.
Fragment-based screening of programmed death ligand 1 (PD-L1).
Bioorg. Med. Chem. Lett., 29:786-790, 2019
Cited by
PubMed: 30728114
DOI: 10.1016/j.bmcl.2019.01.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.426 Å)
Structure validation

217705

數據於2024-03-27公開中

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