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6NH1

Structure of human endothelial nitric oxide synthase heme domain in complex with 6-(3-fluoro-5-(3-(methylamino)prop-1-yn-1-yl)phenethyl)-4-methylpyridin-2-amine

Summary for 6NH1
Entry DOI10.2210/pdb6nh1/pdb
DescriptorEndothelial nitric oxide synthase splice variant eNOS13A, PROTOPORPHYRIN IX CONTAINING FE, 6-(2-{3-fluoro-5-[3-(methylamino)prop-1-yn-1-yl]phenyl}ethyl)-4-methylpyridin-2-amine, ... (10 entities in total)
Functional Keywordsnitric oxide synthase inhibitor complex heme enzyme, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight205521.77
Authors
Chreifi, G.,Li, H.,Poulos, T.L. (deposition date: 2018-12-21, release date: 2019-03-13, Last modification date: 2023-10-11)
Primary citationDo, H.T.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
J. Med. Chem., 62:2690-2707, 2019
Cited by
PubMed: 30802056
DOI: 10.1021/acs.jmedchem.8b02032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.216 Å)
Structure validation

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