6NCN

Fragment-based Discovery of an apoE4 Stabilizer

Summary for 6NCN

Entry DOI	10.2210/pdb6ncn/pdb
Descriptor	Apolipoprotein E, 1-(3-chlorophenyl)cyclobutane-1-carboximidamide (3 entities in total)
Functional Keywords	lipid binding lipid transport, lipid transport
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	21731.91
Authors	Jakob, C.G.,Qiu, W. (deposition date: 2018-12-11, release date: 2019-04-17, Last modification date: 2023-10-11)
Primary citation	Petros, A.M.,Korepanova, A.,Jakob, C.G.,Qiu, W.,Panchal, S.C.,Wang, J.,Dietrich, J.D.,Brewer, J.T.,Pohlki, F.,Kling, A.,Wilcox, K.,Lakics, V.,Bahnassawy, L.,Reinhardt, P.,Partha, S.K.,Bodelle, P.M.,Lake, M.,Charych, E.I.,Stoll, V.S.,Sun, C.,Mohler, E.G. Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer. J.Med.Chem., 62:4120-4130, 2019 Cited by PubMed: 30933499 DOI: 10.1021/acs.jmedchem.9b00178 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation