6N9T

Structure of a peptide-based photo-affinity cross-linker with Herceptin Fc

Summary for 6N9T

Entry DOI	10.2210/pdb6n9t/pdb
Descriptor	Immunoglobulin G1 FC, Photo-affinity peptide, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	crosslinking, antibody, photo-reactive, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	56371.25
Authors	Sadowsky, J.,Ultsch, M.,Vance, N.,Wang, W. (deposition date: 2018-12-04, release date: 2019-01-16, Last modification date: 2020-07-29)
Primary citation	Vance, N.,Zacharias, N.,Ultsch, M.,Li, G.,Fourie, A.,Liu, P.,LaFrance-Vanasse, J.,Ernst, J.A.,Sandoval, W.,Kozak, K.R.,Phillips, G.,Wang, W.,Sadowsky, J. Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies. Bioconjug. Chem., 30:148-160, 2019 Cited by PubMed: 30566343 DOI: 10.1021/acs.bioconjchem.8b00809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.576 Å)

Structure validation