6N9D
Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/L133P/L151C/G154A) with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Summary for 6N9D
| Entry DOI | 10.2210/pdb6n9d/pdb |
| Descriptor | Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | tissue inhibitor of metalloproteinases, matrix metalloproteinase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 39511.44 |
| Authors | Raeeszadeh-Sarmazdeh, M.,Radisky, E.S.,Sankaran, B. (deposition date: 2018-12-03, release date: 2019-05-15, Last modification date: 2023-10-11) |
| Primary citation | Raeeszadeh-Sarmazdeh, M.,Greene, K.A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J.Biol.Chem., 294:9476-9488, 2019 Cited by PubMed: 31040180DOI: 10.1074/jbc.RA119.008321 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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