6N4I

Structural basis of Nav1.7 inhibition by a gating-modifier spider toxin

Summary for 6N4I

• Entry DOI: 10.2210/pdb6n4i/pdb
• Descriptor: Nav1.7 VSD2-NavAb channel chimera protein, Beta/omega-theraphotoxin-Tp2a, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate (3 entities in total)
• Functional Keywords: sodium channel, toxin, gating-modifier, voltage-gated, metal transport
• Biological source: Homo sapiens; More
• Total number of polymer chains: 8
• Total formula weight: 160660.73

Authors

Xu, H.,Koth, C.M.,Payandeh, J. (deposition date: 2018-11-19, release date: 2019-01-23, Last modification date: 2023-10-11)

• Primary citation: Xu, H.,Li, T.,Rohou, A.,Arthur, C.P.,Tzakoniati, F.,Wong, E.,Estevez, A.,Kugel, C.,Franke, Y.,Chen, J.,Ciferri, C.,Hackos, D.H.,Koth, C.M.,Payandeh, J.; Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.; Cell, 176:702-715.e14, 2019; PubMed: 30661758; DOI: 10.1016/j.cell.2018.12.018

Experimental method

X-RAY DIFFRACTION (3.541 Å)