6N48

Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator

Summary for 6N48

Entry DOI	10.2210/pdb6n48/pdb
Descriptor	Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera, Camelid Antibody Fragment, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ... (5 entities in total)
Functional Keywords	g protein coupled receptor, membrane protein, signaling protein
Biological source	Enterobacteria phage RB59 More
Total number of polymer chains	2
Total formula weight	67761.14
Authors	Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Hirata, K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B.K. (deposition date: 2018-11-17, release date: 2019-06-26, Last modification date: 2023-10-11)
Primary citation	Liu, X.,Masoudi, A.,Kahsai, A.W.,Huang, L.Y.,Pani, B.,Staus, D.P.,Shim, P.J.,Hirata, K.,Simhal, R.K.,Schwalb, A.M.,Rambarat, P.K.,Ahn, S.,Lefkowitz, R.J.,Kobilka, B. Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science, 364:1283-1287, 2019 Cited by PubMed: 31249059 DOI: 10.1126/science.aaw8981 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation