6N33

Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622

Summary for 6N33

Entry DOI	10.2210/pdb6n33/pdb
Descriptor	Macrophage colony-stimulating factor 1 receptor, 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine (3 entities in total)
Functional Keywords	csf-1-r, fms proto-oncogene, c-fms, cd115 antigen, kinase, atp-binding, plx5622, transferase-transferase inhibitor complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39035.58
Authors	Zhang, Y. (deposition date: 2018-11-14, release date: 2019-09-18, Last modification date: 2023-10-11)
Primary citation	Spangenberg, E.,Severson, P.L.,Hohsfield, L.A.,Crapser, J.,Zhang, J.,Burton, E.A.,Zhang, Y.,Spevak, W.,Lin, J.,Phan, N.Y.,Habets, G.,Rymar, A.,Tsang, G.,Walters, J.,Nespi, M.,Singh, P.,Broome, S.,Ibrahim, P.,Zhang, C.,Bollag, G.,West, B.L.,Green, K.N. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun, 10:3758-3758, 2019 Cited by PubMed: 31434879 DOI: 10.1038/s41467-019-11674-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation