6N2J

Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C

Summary for 6N2J

Entry DOI	10.2210/pdb6n2j/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kras proto-oncogene, gtpase, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	20221.80
Authors	Vigers, G.P. (deposition date: 2018-11-13, release date: 2018-12-12, Last modification date: 2023-10-11)
Primary citation	Fell, J.B.,Fischer, J.P.,Baer, B.R.,Ballard, J.,Blake, J.F.,Bouhana, K.,Brandhuber, B.J.,Briere, D.M.,Burgess, L.E.,Burkard, M.R.,Chiang, H.,Chicarelli, M.J.,Davidson, K.,Gaudino, J.J.,Hallin, J.,Hanson, L.,Hee, K.,Hicken, E.J.,Hinklin, R.J.,Marx, M.A.,Mejia, M.J.,Olson, P.,Savechenkov, P.,Sudhakar, N.,Tang, T.P.,Vigers, G.P.,Zecca, H.,Christensen, J.G. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med Chem Lett, 9:1230-1234, 2018 Cited by PubMed: 30613331 DOI: 10.1021/acsmedchemlett.8b00382 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation