6MXO

Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG

Summary for 6MXO

• Entry DOI: 10.2210/pdb6mxo/pdb
• Related: 4DL2 4DL3 4DL4 4DL5
• Descriptor: DNA polymerase eta, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... (8 entities in total)
• Functional Keywords: y-family dna polymerase, pt(dach)-gg, transferase-dna-inhibitor complex, nuclear protein, nuclear protein-dna complex, nuclear protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 56983.14

Authors

Ouzon-Shubeita, H.,Lee, S. (deposition date: 2018-10-31, release date: 2019-02-13, Last modification date: 2023-10-11)

• Primary citation: Ouzon-Shubeita, H.,Baker, M.,Koag, M.C.,Lee, S.; Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.; Biochem. J., 476:747-758, 2019; PubMed: 30709915; DOI: 10.1042/BCJ20180848

Experimental method

X-RAY DIFFRACTION (2.04 Å)