6MXO

Structure of HPoleta incorporating dCTP opposite the 3-prime Pt(DACH)-GG

Summary for 6MXO

Related4DL2 4DL3 4DL4 4DL5
DescriptorDNA polymerase eta, DNA (5'-D(*AP*CP*GP*GP*CP*TP*CP*AP*CP*AP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*TP*GP*TP*GP*AP*G)-3'), ... (8 entities in total)
Functional Keywordsy-family dna polymerase, pt(dach)-gg, transferase-dna-inhibitor complex, nuclear protein, nuclear protein-dna complex, nuclear protein/dna
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total molecular weight56983.14
Authors
Ouzon-Shubeita, H.,Lee, S. (deposition date: 2018-10-31, release date: 2019-02-13, Last modification date: 2019-03-13)
Primary citation
Ouzon-Shubeita, H.,Baker, M.,Koag, M.C.,Lee, S.
Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase eta.
Biochem. J., 476:747-758, 2019
PubMed: 30709915 (PDB entries with the same primary citation)
DOI: 10.1042/BCJ20180848
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.04 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2405 0.2% 1.9% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6mxo
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Molmil generated image of 6mxo
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Molmil generated image of 6mxo
rotated about y axis by 90°