6MTI

Synaptotagmin-1 C2A, C2B domains and SNARE-pin proteins (5CCI) individually docked into Cryo-EM map of C2AB-SNARE complexes helically organized on lipid nanotube surface in presence of Mg2+

Summary for 6MTI

Entry DOI	10.2210/pdb6mti/pdb
EMDB information	9231
Descriptor	Synaptotagmin-1, Vesicle-associated membrane protein 2, Syntaxin-1A, ... (7 entities in total)
Functional Keywords	snare, lipid nanotubes, exocytosis
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	30
Total formula weight	347964.38
Authors	Grushin, K.,Wang, J.,Coleman, J.,Rothman, J.,Sindelar, C.,Krishnakumar, S. (deposition date: 2018-10-19, release date: 2019-04-24, Last modification date: 2024-03-13)
Primary citation	Grushin, K.,Wang, J.,Coleman, J.,Rothman, J.E.,Sindelar, C.V.,Krishnakumar, S.S. Structural basis for the clamping and Ca2+activation of SNARE-mediated fusion by synaptotagmin. Nat Commun, 10:2413-2413, 2019 Cited by PubMed: 31160571 DOI: 10.1038/s41467-019-10391-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (10.4 Å)

Structure validation