6MOO

Co-Crystal structure of P. aeruginosa LpxC-achn975 complex

Summary for 6MOO

• Entry DOI: 10.2210/pdb6moo/pdb
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S)-3-azanyl-3-methyl-1-(oxidanylamino)-1-oxidanylidene-butan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta -1,3-diynyl]benzamide, ... (4 entities in total)
• Functional Keywords: hydrolase lpxc pseudomonas aeruginosa, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 1
• Total formula weight: 34141.94

Authors

Stein, A.J.,Assar, Z.,Holt, M.C.,Cohen, F.,Andrews, L.,Cirz, R. (deposition date: 2018-10-04, release date: 2019-07-17, Last modification date: 2023-10-11)

• Primary citation: Cohen, F.,Aggen, J.B.,Andrews, L.D.,Assar, Z.,Boggs, J.,Choi, T.,Dozzo, P.,Easterday, A.N.,Haglund, C.M.,Hildebrandt, D.J.,Holt, M.C.,Joly, K.,Jubb, A.,Kamal, Z.,Kane, T.R.,Konradi, A.W.,Krause, K.M.,Linsell, M.S.,Machajewski, T.D.,Miroshnikova, O.,Moser, H.E.,Nieto, V.,Phan, T.,Plato, C.,Serio, A.W.,Seroogy, J.,Shakhmin, A.,Stein, A.J.,Sun, A.D.,Sviridov, S.,Wang, Z.,Wlasichuk, K.,Yang, W.,Zhou, X.,Zhu, H.,Cirz, R.T.; Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.; Chemmedchem, 14:1560-1572, 2019; PubMed: 31283109; DOI: 10.1002/cmdc.201900287

Experimental method

X-RAY DIFFRACTION (2.2 Å)