6MON

Crystal structure of human SMYD2 in complex with Nle-peptide inhibitor

Summary for 6MON

• Entry DOI: 10.2210/pdb6mon/pdb
• Descriptor: N-lysine methyltransferase SMYD2, LYS-LEU-NLE-SER-LYS-ARG-GLY, ZINC ION, ... (6 entities in total)
• Functional Keywords: methyltransferase, norleucine, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 101548.56

Authors

Spellmon, N.,Cornett, E.,Brunzelle, J.,Rothbart, S.,Yang, Z. (deposition date: 2018-10-04, release date: 2018-12-12, Last modification date: 2023-11-15)

• Primary citation: Cornett, E.M.,Dickson, B.M.,Krajewski, K.,Spellmon, N.,Umstead, A.,Vaughan, R.M.,Shaw, K.M.,Versluis, P.P.,Cowles, M.W.,Brunzelle, J.,Yang, Z.,Vega, I.E.,Sun, Z.W.,Rothbart, S.B.; A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.; Sci Adv, 4:eaav2623-eaav2623, 2018; PubMed: 30498785; DOI: 10.1126/sciadv.aav2623

Experimental method

X-RAY DIFFRACTION (2.711 Å)