6MNP

Crystal structure of KPC-2 with compound 6

6MNP の概要

• エントリーDOI: 10.2210/pdb6mnp/pdb
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: carbapenemase, tetrazole, inhibitor, complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31763.71

構造登録者

Akhtar, A.,Chen, Y. (登録日: 2018-10-02, 公開日: 2019-04-17, 最終更新日: 2023-10-11)

• 主引用文献: Torelli, N.J.,Akhtar, A.,DeFrees, K.,Jaishankar, P.,Pemberton, O.A.,Zhang, X.,Johnson, C.,Renslo, A.R.,Chen, Y.; Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.; Acs Infect Dis., 5:1013-1021, 2019; PubMed: 30942078; DOI: 10.1021/acsinfecdis.9b00052

実験手法

X-RAY DIFFRACTION (2.202 Å)