6MLL
Crystal structure of KPC-2 with compound 7
Summary for 6MLL
| Entry DOI | 10.2210/pdb6mll/pdb |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, 1,5-diphenyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-3-carboxamide, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | carbapenemase, tetrazole, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 31230.06 |
| Authors | Akhtar, A.,Chen, Y. (deposition date: 2018-09-27, release date: 2019-04-17, Last modification date: 2023-10-11) |
| Primary citation | Torelli, N.J.,Akhtar, A.,DeFrees, K.,Jaishankar, P.,Pemberton, O.A.,Zhang, X.,Johnson, C.,Renslo, A.R.,Chen, Y. Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. Acs Infect Dis., 5:1013-1021, 2019 Cited by PubMed: 30942078DOI: 10.1021/acsinfecdis.9b00052 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.86 Å) |
Structure validation
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