6ME8

XFEL crystal structure of human melatonin receptor MT2 (N86D) in complex with 2-phenylmelatonin

Summary for 6ME8

Entry DOI	10.2210/pdb6me8/pdb
Descriptor	Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, ZINC ION (3 entities in total)
Functional Keywords	gpcr, melatonin receptor type 1b (mt2), n86d mutation, membrane protein, 2-phenylmelatonin, xfel, lcp, bril, rubredoxin, circadian rhythm, jetlag, type 2 diabetes
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	103713.29
Authors	Johansson, L.C.,Stauch, B.,McCorvy, J.,Han, G.W.,Patel, N.,Batyuk, A.,Gati, C.,Li, C.,Grandner, J.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V. (deposition date: 2018-09-05, release date: 2019-04-24, Last modification date: 2023-10-11)
Primary citation	Johansson, L.C.,Stauch, B.,McCorvy, J.D.,Han, G.W.,Patel, N.,Huang, X.P.,Batyuk, A.,Gati, C.,Slocum, S.T.,Li, C.,Grandner, J.M.,Hao, S.,Olsen, R.H.J.,Tribo, A.R.,Zaare, S.,Zhu, L.,Zatsepin, N.A.,Weierstall, U.,Yous, S.,Stevens, R.C.,Liu, W.,Roth, B.L.,Katritch, V.,Cherezov, V. XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity. Nature, 569:289-292, 2019 Cited by PubMed: 31019305 DOI: 10.1038/s41586-019-1144-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation