XFEL crystal structure of human melatonin receptor MT1 in complex with 2-phenylmelatonin

Summary for 6ME3

Descriptorchimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-[2-(5-methoxy-2-phenyl-1H-indol-3-yl)ethyl]acetamide, OLEIC ACID, ... (5 entities in total)
Functional Keywordsgpcr, melatonin receptor type 1a (mt1), 2-phenylmelatonin, membrane protein, xfel, lcp, pgs, circadian rhythm, jetlag
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight57294.31
Primary citation
Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Huang, X.P.,Gati, C.,Batyuk, A.,Slocum, S.T.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Shiriaeva, A.,Olsen, R.H.J.,Tribo, A.R.,Yous, S.,Stevens, R.C.,Weierstall, U.,Katritch, V.,Roth, B.L.,Liu, W.,Cherezov, V.
Structural basis of ligand recognition at the human MT1melatonin receptor.
Nature, 2019
PubMed: 31019306 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-019-1141-3
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2523 0.2% 2.6% 5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6me3
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Molmil generated image of 6me3
rotated about x axis by 90°
Molmil generated image of 6me3
rotated about y axis by 90°