6ME2

XFEL crystal structure of human melatonin receptor MT1 in complex with ramelteon

6ME2 の概要

• エントリーDOI: 10.2210/pdb6me2/pdb
• 分子名称: chimera protein of Melatonin receptor type 1A and GlgA glycogen synthase, N-{2-[(8S)-1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl]ethyl}propanamide, OLEIC ACID, ... (5 entities in total)
• 機能のキーワード: gpcr, melatonin receptor type 1a (mt1), membrane protein, ramelteon, xfel, lcp, pgs, circadian rhythm, jetlag
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57584.79

構造登録者

Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Gati, C.,Batyuk, A.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Olsen, R.H.J.,Tribo, A.R.,Weierstall, U.,Roth, B.L.,Katritch, V.,Liu, W.,Cherezov, V. (登録日: 2018-09-05, 公開日: 2019-04-24, 最終更新日: 2023-10-11)

• 主引用文献: Stauch, B.,Johansson, L.C.,McCorvy, J.D.,Patel, N.,Han, G.W.,Huang, X.P.,Gati, C.,Batyuk, A.,Slocum, S.T.,Ishchenko, A.,Brehm, W.,White, T.A.,Michaelian, N.,Madsen, C.,Zhu, L.,Grant, T.D.,Grandner, J.M.,Shiriaeva, A.,Olsen, R.H.J.,Tribo, A.R.,Yous, S.,Stevens, R.C.,Weierstall, U.,Katritch, V.,Roth, B.L.,Liu, W.,Cherezov, V.; Structural basis of ligand recognition at the human MT1melatonin receptor.; Nature, 569:284-288, 2019; PubMed: 31019306; DOI: 10.1038/s41586-019-1141-3

実験手法

X-RAY DIFFRACTION (2.8 Å)