6MAV

Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix metalloproteinase-3 catalytic domain (MMP-3cd)

Summary for 6MAV

Entry DOI	10.2210/pdb6mav/pdb
Descriptor	Stromelysin-1, Metalloproteinase inhibitor 1, CALCIUM ION, ... (5 entities in total)
Functional Keywords	protease inhibitor, matrix metalloproteinase-3 (mmp-3), tissue inhibitor of metalloproteinase-1 (timp-1), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	39814.82
Authors	Raeeszadeh-Sarmazdeh, M.,Radisky, E. (deposition date: 2018-08-28, release date: 2019-05-15, Last modification date: 2023-10-11)
Primary citation	Raeeszadeh-Sarmazdeh, M.,Greene, K.A.,Sankaran, B.,Downey, G.P.,Radisky, D.C.,Radisky, E.S. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J.Biol.Chem., 294:9476-9488, 2019 Cited by PubMed: 31040180 DOI: 10.1074/jbc.RA119.008321 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation